Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies
نویسندگان
چکیده
منابع مشابه
Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies
Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease, characterized by chronic, erosive polyarthritis and by the presence of various autoantibodies in serum and synovial fluid. Since rheumatoid factor (RF) was first described, a number of other autoantibodies have been discovered in RA patients. The autoantigens recognized by these autoantibodies include cartilage components,...
متن کاملAnticitrullinated protein/peptide antibodies in rheumatoid arthritis.
R heumatoid arthritis (RA) is a chronic systemic autoimmune disease and is the most frequent form of inflammatory joint disease. The prevalence is between 0.5% and 1%; women are affected about three times more often than men. The prevalence increases to about 2% in the fourth and fifth decades of life. RA is characterized by symmetrical, eroding joint synovitis. The systemic character of the di...
متن کاملAnticardiolipin Antibodies in Juvenile Rheumatoid Arthritis and Systemic Lupus Erythematosus
Background: Antiphospholipid antibody syndrome (APS) can either occur as a primary syndrome or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Anticardiolipin antibody (aCL) of IgG and/or IgM isotype in blood, measured by a standardized ELISA is the most acceptable laboratory criteria. APS IgG isotype, particularly IgG2 subclass is more strongly associated ...
متن کاملThe effects of rheumatoid factor and anticitrullinated peptide antibodies on bone erosions in rheumatoid arthritis.
With interest we read the article by Hecht et al who studied the associations of anticitrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) with bone erosions in rheumatoid arthritis (RA). The background of this study was that ACPAs directed against citrullinated vimentin induce differentiation of osteoclasts, indicating that ACPA has a direct effect on bone resorption. No biologica...
متن کاملAutoantibodies in rheumatoid arthritis
(e--mail: [email protected]) Although the incidence and prevalence of individual autoimmune diseases are not high (table), the population burden of the disease is large and underestimated. Serum autoantibodies, which appear long before onset of clinical disease, are a characteristic feature, as recently emphasised by Markus Nielen and colleagues. Studying patients with rheumatoid arth...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: QJM
سال: 2009
ISSN: 1460-2725,1460-2393
DOI: 10.1093/qjmed/hcp165